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tDCS helps restore brain activity

Depression is associated with lowered brain activity, which leads to decreased cognitive control ultimately contributing to dysfunctional emotional processing. tDCS helps restore brain activity.

Results comparable to drug treatment

The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care.

Personalised tDCS gives maximum benefit

Identical stimulation parameters induce different physiological, behavioral, and therapeutic effects across individuals. Personalisation maximizes tDCS therapeutic response in individual patients.

Superior combined therapy

The clinical superiority of a combined therapeutic approach of tDCS and Cognitive Control Therapy is evident.

Latest Research on tDCS for Depression
  1. From British Journal of Psychiatry(Journal impact factor 7.85) Transcranial direct current stimulation for acute major depressive episodes: meta-analysis of individual patient data

    • “ The effect size of tDCS treatment was comparable with those reported for repetitive transcranial magnetic stimulation and antidepressant drug treatment in primary care. ” affective 34% of the time in comparison to sham’s 19%, with NNT 7. The NNTs of rTMS and anti-depressants is between 7 and 9. Lower NNT, the better.“

  2. From Depression and Anxiety  (Journal impact factor 5.46), A systematic review and meta-analysis on the effects of transcranial direct current stimulation in depressive episodes

    • “Active tDCS was superior to sham with response rates of active 33.3% vs. sham 16.56% and NNT = 6”. Moreover, active tDCS was as acceptable as a sham. No risk of publication bias was identified. Cumulative meta-analysis showed that effect sizes are basically unchanged since the total sample reached 439 participants.”

  3. From (Journal impact factor 4.3), Efficacy and acceptability of transcranial direct current stimulation (tDCS) for major depressive disorder: An individual patient data meta-analysis 

    • Another IPD meta-analysis (n=572), showed that compared to sham, active tDCS significantly improved depression with a response rate of 30.9% vs. a sham rate of 18.9% and NNT of 9

  4. From the International Journal of Neuropsychopharmacology (Journal Impact Factor 4.39) Evidence-based guidelines and secondary meta-analysis for the use of transcranial direct current stimulation (tDCS) in neurological and psychiatric disorders 

    • The best researchers researching tDCS from around the world have come together to write a paper on how effective tDCS is for neurological and psychological functions. Stimulation using tDCS to Anodal left DLPFC is acknowledged as definitely effective(Level A)  in improving depression in Major Depressive Disorder (MDD).

Neuro-Biological effects of Depression

Depression corresponds to reduced activity in your left-DLPFC(Dorsolateral Prefrontal Cortex) and an increased activity in your right-DLPFC.

  1. From, Nature Reviews Neuroscience (Journal Impact factor 33), Neural mechanisms of the cognitive model of depression

  2. From Biological Psychiatry (Journal Impact factor 12), Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder 

The MDD patients showed hypoactivity in the left DLPFC during both unattended and attended emotional judgment and hyperactivity in the right DLPFC during attended emotional judgment. In contrast to healthy subjects, left DLPFC activity during emotional judgment was not parametrically modulated by negative emotional valence and was inversely modulated by positive emotional valence in MDD patients. Hyperactivity in the right DLPFC correlated with depression severity.

Altered function bilaterally in the DLPFC has been associated with decreased cognitive control, thereby facilitating heightened amygdala reactivity and ultimately contributing to dysfunctional emotional processing

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